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Previously, people that were taking Cardarine alone experienced a gradual decrease in their fat cells, but they also had to grapple with the fact that they would also be losing some musclemass at the same time. Now, that hasn't happened, and they are still getting more than they were before. "The change in the levels of glucose in their bodies has slowed down, allowing them to do some things better and some things better than before," says Dr. David Katz, who heads the Cardarine Research and Development Center at UCLA. "And this is good because with exercise, carbohydrates are burned as fuel for most of the energy expenditure in the body. These effects of Cardarine are probably being caused by the metabolic rate of the body slowing in response to some type of metabolic stimulus." That has implications for future research on how Cardarine can affect weight loss, though it's a long way off. Researchers from the Institute of Psychiatry in London and the Wellcome Trust Sanger Institute have reported preliminary results from a randomized, controlled trial. After six weeks of treatment with a daily 500 milligram Cardarine tablet containing only a tiny slice of Cardarine, patients showed a greater weight loss than during eight months of diet and exercise alone. The study, which included nearly 450 participants of both sexes, will have to be repeated to draw any conclusions about longer-term effects on weight and longevity. It's one of the few studies that has examined how Cardarine may impact the body more broadly, rather than focusing on cardiovascular disease. The bottom line is that Cardarine, if used as directed, offers some real advantages over other anti-obesity drugs. It's a dietary compound, and since most of the anti-obesity drugs have carbohydrates (such as glucose, fructose and lactose), the effect on blood sugar can be huge. In a study of people who took anti-obesity drugs and continued a high-carbohydrate diet, those treated with Cardarine saw a 27 percent weight loss, compared with 21 percent for those treated with placebo. "Cardarine has the benefit of not being a carbohydrate, which is the main problem with other anti-obesity drugs," Katz says. "The carbs will get broken down into glucose and be used for energy." That means there are fewer side effects, he adds, including weight gain and insulin resistance. If the effect lasts, Cardarine could one day give people who wish to ditch their current regimen of anti-obesity drugs a way to go, while preserving a degree of fat-free tissue. (A study published in the same issue of the Journal of Clinical Endocrinology & Metabolism on Dec. 17, 2008, Related Article: